准教授・坂本 毅治

<理念・モットー>

人事を尽くして天明を待つ

個性を生かしたチーム作り

 

<趣味>

飲み会、旅先でご当地名物を食べること、育児

 

<生い立ち>

1996年 福岡県立小倉高等学校卒業

2002年 東京大学農学部獣医学課程獣医学専修卒業

2003年 日本学術振興会特別研究員(DC1)

2006年 東京大学大学院医学系研究科病因・病理学専攻単位取得後退学

2006年 東京大学大学院新領域創成科学研究科、リサーチフェロー

2007年  東京大学大学院医学系研究科病因・病理学専攻学位取得、博士(医学)

2008年 東京大学医科学研究所、腫瘍細胞社会学分野、特任研究員

2009年 東京大学医科学研究所、腫瘍細胞社会学分野、助教

2013年 東京大学医科学研究所、抗体・ワクチン治療研究部門、特任助教

2014年 東京大学医科学研究所、人癌病因遺伝子分野、助教

2018年 東京大学医科学研究所、分子発癌分野、准教授

 

<資格>

獣医師免許

 

<所属学会>

本癌学会、日本分子生物学会、日本がん転移学会(評議員)、日本がん分子標的治療学会

 

<賞罰等>

平成27年 日本がん転移学会 奨励賞

平成29年 日本癌学会 奨励賞

 

<業績>

  • Novel adherent CD11b+ Gr-1+ tumor-infiltrating cells initiate an immunosuppressive tumor microenvironment. Tsubaki T, Kadonosono T, Sakurai S, Shiozawa T, Goto T, Sakai S, Kuchimaru T, Sakamoto T, Watanabe H, Kondoh G, Shinae Kizaka-Kondoh*. Oncotarget. 9, 11209-11226 (2018).
  • Deficiency of a membrane skeletal protein, 4.1G, results in myelin abnormalities in the peripheral nervous system. Saitoh Y, Ohno N, Yamauchi J, Sakamoto T, Terada N*. Histochem Cell Biol. 148, 597-606 (2017).
  • Mint3 in bone marrow-derived cells promotes lung metastasis in breast cancer model mice. Hara T, Murakami Y, Seiki M, Sakamoto T*. Biochem Biophys Res Commun. 490, 688-692 (2017).
  • Sakamoto T*, Seiki M*. Integrated functions of membrane-type 1 matrix metalloproteinase in regulating cancer malignancy: beyond a proteinase. Cancer Sci. 108, 1095-1100 (2017).
  • Hara T, Nakaoka HJ, Hayashi T, Mimura K, Hoshino D, Inoue M, Nagamura F, Murakami Y, Seiki M, Sakamoto T*. Control of metastatic niche formation by targeting APBA3/Mint3 in inflammatory monocytes. Proc Natl Acad Sci USA. 114, E4416-E4424 (2017).
  • Nakaoka HJ, Tanei Z, Hara T, Weng JS, Kanamori A, Hayashi T, Sato H, Orimo A, Otsuji K, Tada K, Morikawa T, Sasaki T, Fukayama M, Seiki M, Murakami Y, Sakamoto T*. Mint3-mediated L1CAM expression in fibroblasts promotes cancer cell proliferation via integrin α5β1 and tumour growth. Oncogenesis. 6, e334 (2017).
  • Uematsu T, Fujita T, Nakaoka HJ, Hara T, Kobayashi N, Murakami Y, Seiki M, Sakamoto T*. Mint3/Apba3 depletion ameliorates severe murine influenza pneumonia and macrophage cytokine production in response to the influenza virus. Sci Rep. 6, 37815 (2016).
  • Huai W, Song H, Yu Z, Wang W, Han L, Sakamoto T, Seiki M, Zhang L, Zhang Q, and Zhao W*. Mint3 potentiates TLR3/4- and RIG-I-induced IFN-β expression and antiviral immune responses. Proc Natl Acad Sci USA. 113, 11925-11930 (2016).
  • Yoshino S, Hara T, Nakaoka HJ, Kanamori A, Murakami Y, Seiki M, Sakamoto T*. The ERK-signaling target RNF126 regulates anoikis resistance in cancer cells by changing the mitochondrial metabolic flux. Cell Discov. 2, 16019 (2016).
  • Nakaoka HJ, Hara T, Yoshino S, Kanamori A, Matsui Y, Shimamura T, Sato H, Murakami Y, Seiki M, Sakamoto T*. NECAB3 promotes activation of hypoxia-inducible factor-1 during normoxia and enhances tumourigenicity of cancer cells. Sci Rep. 6, 22784 (2016).
  • Temma T, Hanaoka H, Yonezawa A, Kondo N, Sano K, Sakamoto T, Seiki M, Ono M, Saji H*. Investigation of a MMP-2 Activity-Dependent Anchoring Probe for Nuclear Imaging of Cancer, PLoS One. 9, e102180 (2014).
  • Sakamoto T, Weng JS, Hara T, Yoshino S, Kozuka-Hata H, Oyama M, Seiki M*. Hypoxia-Inducible Factor 1 Regulation through Cross Talk between mTOR and MT1-MMP. Mol Cell Biol. 34, 30-42 (2014).
  • Nishida C, Kusubata K, Tashiro Y, Gritli I, Sato A, Ohki-Koizumi M, Morita Y, Nagano M, Sakamoto T, Koshikawa N, Kuchimaru T, Kizaka-Kondoh S, Seiki M, Nakauchi H, Heissig B, Hattori K*. MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemokine/cytokine gene transcription within niche cells. Blood. 119, 5405-5416 (2012).
  • Yoshino S, Hara T, Weng JS, Takahashi Y, Seiki M*, Sakamoto T. Genetic screening of new genes responsible for cellular adaptation to hypoxia using a genome-wide shRNA library. PLoS One. 7, e35590 (2012).
  • Hara T, Mimura K, Seiki M*, Sakamoto T. Genetic dissection of proteolytic and non-proteolytic contributions of MT1-MMP to macrophage invasion. Biochem Biophys Res Commun. 413, 277-281 (2011).
  • Hara T, Mimura K, Abe T, Shioi G, Seiki M*, Sakamoto T. Deletion of the Mint3/APBA3 gene in mice abrogates macrophage functions and increases resistance to lipopolysaccaride-induced septic shock. J Biol Chem. 286, 32542-32551 (2011).
  • Sakamoto T, Niiya D, Seiki M*. Targeting the warburg effect, which arises in tumor cells expressing membrane-type-1 matrix metalloproteinase. J Biol Chem. 286, 14691-14704 (2011).
  • Nagano M, Hoshino D, Sakamoto T, Akizawa T, Koshikawa N, Seiki M*. ZF21 is a new regulator of focal adhesion disassembly and a potential member of the spreading initiation center. Cell Adh Migr. 5, 23-28 (2011).
  • Sakamoto T, Seiki M*. A membrane protease regulates energy production in macrophages by activating hypoxia-inducible factor-1 via a non-proteolytic mechanism. J Biol Chem. 285, 29951-29964 (2010).
  • Nagano M, Hoshino D, Sakamoto T, Kawasaki N, Koshikawa N, Seiki M*. ZF21 protein regulates cell adhesion and motility. J Biol Chem. 285, 21013-21022 (2010). 
  • Sakamoto T, Seiki M*. Mint3 enhances the activity of hypoxia-inducible factor-1 (HIF-1) in macrophages by suppressing the activity of factor inhibiting HIF-1. J Biol Chem. 284, 30350-30359 (2009).
  • Niiya D, Egawa N, Sakamoto T, Kikkawa Y, Shinkawa T, Isobe T, Koshikawa N, Seiki M*. Identification and characterization of Lutheran blood group glycoprotein as a new substrate of membrane-type 1 matrix metalloproteinase 1 (MT1-MMP): a systemic whole cell analysis of MT1-MMP-associating proteins in A431 cells. J Biol Chem. 284, 27360-27369 (2009).
  • Sakamoto T, Seiki M*. Cytoplasmic tail of MT1-MMP regulates macrophage motility independently from its protease activity. Genes Cells. 14, 617-626 (2009).
  • Rikimaru A, Komori K, Sakamoto T, Ichise H, Yoshida N, Yana I, Seiki M*. Establishment of an MT4-MMP-deficient mouse strain representing an efficient tracking system for MT4-MMP/MMP-17 expression in vivo using beta-galactosidase. Genes Cells. 12, 1091-1100 (2007).
  • Taniwaki K, Fukamachi H, Komori K, Ohtake Y, Nonaka T, Sakamoto T, Shiomi T, Okada Y, Itoh T, Itohara S, Seiki M, Yana I*. Stroma-derived matrix metalloproteinase (MMP)-2 promotes membrane type 1-MMP-dependent tumor growth in mice. Cancer Res. 67, 4311-4319 (2007).
  • Shimizu S, Saito N, Kubosaki A, SungWook S, Takeyama N, Sakamoto T, Matsumoto Y, Saeki K, Matsumoto Y, Onodera T*. Developmental expression and localization of IA-2 mRNA in mouse neuroendocrine tissues. Biochem Biophys Res Commun. 288, 165-171 (2001).