Paper & Review

  

2017年

  

  • Koga, R., Radwan, M.O., Ejima, T., Kanemaru, Y., Tateishi, H., Ali, T.F.C., Ciftci, H.I., Shibata, Y., Taguchi, Y., Inoue, J., Otsuka M. and Fujita, M.* A Dithiol Compound Binds to the Zinc Finger Protein TRAF6 and Suppresses its Ubiquitination. ChemMedChem in press (2017) doi:10.1002/cmdc.201700399 
  • Magilnick, N., Reyes, E.Y., Wang, W-L., Vonderfecht, S.L., Gohda, J., Inoue, J. and Boldin, M.P. The miR-146a-Traf6 regulatory axis controls autoimmunity and myelopoiesis, but is dispensable for hematopoietic stem cell homeostasis and tumor suppression. Proc. Natl. Acad. Sci. USA (2017). doi:10.1073/pnas.1706833114.
  • Inuki, S., Aiba, T., Kawakami,S., Akiyama, T., Inoue, J. and Fujimoto, Y. Total synthesis of D-glycero-D-manno-Heptose 1,7-Bisphosphate and evaluation of its ability to modulate  NF-κB Activation. Org. Lett. (2017). doi:10.1021/acs.orglett.7b01158. [Epub ahead of print]
  • Into, T., Horie, T., Inomata1, M., Gohda, J., Inoue, J., Murakami, Y. and Niida., S. Basal autophagy prevents autoactivation or enhancement of inflammatory signals by targeting monomeric MyD88. Sci. Rep. 7: 1009. doi:10.1038/s41598-017-01246-w (2017).
  • Yamamoto M., Sakane K., Tominaga K., Gotoh N., Niwa T., Kikuchi Y., Tada K., Goshima N., Semba K. and Inoue J.
    Intratumoral bidirectional transitions between epithelial and mesenchymal cells in triple-negative breast cancer.
    Cancer Sci.  108, 1210-1222 (2017) doi:10.1111/cas.13246.
  • Shibata Y., Tokunaga F., Goto E., Komatsu G., Gohda J., Saeki Y., Tanaka K., Takahashi H., Sawasaki T., Inoue S., Oshiumi H., Seya T., Nakano H., Tanaka Y., Iwai K. and Inoue J.
    HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains.
    PLoS Pathogens 13(1):e1006162. doi:10.1371/journal.ppat.1006162 (2017).
  • Varney M., Choi K., Bolanos L., Christie S., Fang J., Grimes L., Maciejewski J., Inoue J. and Starczynowski D.
    Epistasis between TIFAB and miR-146a, neighboring genes in del(5q) MDS.
    Leukemia 31, 491–495; doi:10.1038/leu.2016.276 (2017)

 

2016年

 

  • Yu J., Yun H., Shin B., Kim Y., Park E.S., Choi S., Yu J., Amarasekara D.S., Kim S., Inoue J., Walsh M.C., Choi Y., Takami M. and Rho J.*
    Interaction of tumor necrosis factor receptor-associated factor 6 (TRAF6) and Vav3 in the receptor activator of nuclear factor κB (RANK) signaling complex enhances osteoclastogenesis.
    J. Biol. Chem. 291(39):20643-60. doi:10.1074/jbc.M116.728303. (2016)
  • Yamamoto M., Matsuyama S., Li X., Takeda M., Kawaguchi Y., Inoue J., and Matsuda Z.
    Identification of nafamostat as a potent inhibitor of Middle East respiratory syndrome (MERS) corona virus S-mediated membrane fusion using the split protein-based cell-cell fusion assay. 
    Antimicrob. Agents Chemotherpii: AAC.01043-16. [Epub ahead of print] (2016)
    (医科研HPに内容解説プレスリリースが有ります。)
  • Kawasaki M., Kawasaki K., Oommen S., Blackburn J., Watanabe M., Nagai T., Kitamura A., Maeda T., Liu B., Schmidt-Ullrich R., Akiyama T., Inoue J., Hammond N.L., Sharpe P.T. and Ohazama A.* 
    Regional regulation of filiform tongue papillae development by Ikkα/Irf6.
    Dev. Dyn. doi: 10.1002/dvdy.24427 (2016)
  • Akiyama N., Takizawa N., Miyauchi M., Yanai H., Tateishi R., Shinzawa M., Yoshinaga R., Kurihara M., Demizu Y., Yasuda H., Yagi S., Wu G., Matsumoto M., Sakamoto R., Yoshida N., Penninger J. M., Kobayashi Y., Inoue J., Akiyama T.
    Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator. 
    J. Exp. Med. 213(8):1441-1458, doi: 10.1084/jem.20151780 (2016) 
    (医科研HPに内容解説が有ります。)
  • Narushima Y., Kozuka-Hata H., Tsumoto K., Inoue J., Oyama M.
    Quantitative phosphoproteomics-based molecular network description for high-resolution kinase-substrate interactome analysis. 
    Bioinformatics (2016) doi:10.1093/bioinformatics/btw164
  • Narushima Y., Kozuka-Hata H., Koyama-Nasu R., Tsumoto K., Inoue J., Akiyama T., Oyama M.
    Integrative Network Analysis Combined with Quantitative Phosphoproteomics Reveals TGFBR2 as a Novel Regulator of Glioblastoma Stem Cell Properties. 
    Mol. Cell. Proteomics  15(3), 1017-1031. (2016)

 

2015年

 

  • Tateishi R., Akiyama N., Miyauchi M., Yoshinaga R., Sasanuma H., Kudo T., Shimbo M., Shonohara M., Obata K., Inoue J., Shirakawa M., Shiba D., Asahara H., Yoshida N., Takahashi S., Morita H., & Akiyama T.
    Hypergravity provokes a temporary reduction in CD4+CD8+ thymocyte number and a persistent decrease in medullary thymic epithelial cell frequency in mice. 
    PLoS ONE 10(10): e0141650. doi:10.1371/journal.pone.0141650 (2015)
  • Varney M.E., Niederkorn M., Konno H., Matsumura T., Gohda J., Yoshida N., Akiyama T., Christie S., Fang J., Miller D., Jerez A., Karsan A., Maciejewski J.P., Inoue J. & Starczynowski D.T. 
    Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling.
    J. Exp. Med. 212(11) 1967-1985, doi:10.1084/jem.20141898 (2015)
  • Taguchi Y., Gohda J., & Inoue J. 
    NF-κB Signaling in Osteoclastogenesis. 
    Protein Modifications in Pathogenic Dysregulation of Signaling edited by Jun-ichiro Inoue and Mutsuhiro Takekawa
    Springer Press, p197-210 (2015)
  • Ohshima D., Inoue J., & Ichikawa K. 
    Potential Roles of Spatial Parameters in the Regulation of NF-κB Oscillations, as Revealed by Computer Simulations. 
    Protein Modifications in Pathogenic Dysregulation of Signaling edited by Jun-ichiro Inoue and Mutsuhiro Takekawa
    Springer Press, p63-75 (2015)
  • Seki T., Yamamoto M., Taguchi Y., Miyauchi M., Yamaguchi N., Gohda J., Akiyama T. & Inoue J. 
    Visualization of RelB expression and activation at the single-cell level during dendritic cell maturation in Relb-Venus knock-in mice.
    J. Biochem. 158(6), 485-495 doi:10.1093/jb/mvv064 (2015) 
  • Shinzawa M., Konno H., Qin J., Akiyama N., Miyauchi M., Ohashi H., Miyamoto-Sato E., Yanagawa H., Akiyama T. & Inoue J. 
    Catalytic subunits of the phosphatase calcineurin interact with NF-κB-inducing kinase (NIK) and attenuate NIK-dependent gene expression.
    Sci. Rep. 5, 10758; doi: 10.1038/srep10758 (2015)
  • Sato, Y., Goto, E., Shibata, Y., Kubota, Y., Yamagata, A., Goto-Ito, S., Kubota, K., Inoue, J., Takekawa, M., Tokunaga, F. & Fukai, S. 
    Structures of CYLD USP with Met1- or Lys63-linked diubiquitin reveal mechanisms for dual specificity.
    Nat. Struct. Mol. Biol. 22(3), 222-229. (2015)
  • Gohda, J., Ma, Y., Huang, Y., Zhang, Y., Gu, L., Han, Y., Li, T., Gao, G.F., Inoue, J., Iwamoto, A. & Ishida, T. 
    HIV-1 replicates in human osteoclasts and enhances their differentiation in vitro.
    Retrovirology 12:12. doi: 10.1186/s12977-015-0139-7.(2015)
  • Ito-Kureha, T., Koshikawa, N., Yamamoto, M., Semba, K., Yamaguchi, N., Yamamoto, T., Seiki, M. and Inoue, J.
    Tropomodulin 1 expression driven by NF-κB enhances breast cancer growth. 
    Cancer Res. 75, 62-72. (2015)
  • Blackburn, J., Kawasaki, K., Porntaveetus, T., Kawasaki, M., Otsuka-Tanaka, Y., Miake, Y., Ota, M.S., Watanabe, M., Hishinuma, M., Nomoto, T., Oommen, S., Ghafoor, S., Harada, F., Nozawa-Inoue, K., Maeda, T., Peterková, R., Lesot, H., Inoue, J., Akiyama, T., Schmidt-Ullrich, R., Liu, B., Hu, Y., Page, A., Ramírez, A., Sharpe, P.T. and Ohazama, A.
    Excess NF-κB induces ectopic odontogenesis in embryonic incisor epithelium. 
    J. Dent. Res. 94(1), 121-128. (2015)

 

2014年

 

  • Akiyama, N., Shinzawa, M., Miyauchi, M., Yanai, H., Tateishi, R., Shimo, Y., Ohshima, D., Matsuo, M., Sasaki, I., Hoshino, K., Wu, G., Yagi, S., Inoue, J., Kaisho, T. and Akiyama, T.
    Limitation of immune tolerance-inducing thymic epithelial cell development by Spi-B-mediated negative feedback regulation. 
    J. Exp. Med.  211(12), 2425-2438. (2014)
  • Akiyama, T., Shiraishi, T., Qin, J., Konno, H., Akiyama, N., Shinzawa, M., Miyauchi, M., Takizawa, N., Yanai, H., Ohashi, H., Miyamoto-Sato, E., Yanagawa, H., Yong, W., Shou, W. and Inoue, J.
    Mitochondria–nucleus shuttling FK506-binding protein 51 interacts with TRAF proteins and facilitates the RIG-I-like receptor-mediated expression of type I IFN. 
    PLoS ONE 9(5), e95992. (2014)

 

2013年

 

  • Yamaguchi, N., Oyama, M., Kozuka-Hata, H. and Inoue, J.
    Involvement of A20 in the molecular switch that activates the non-canonical NF-κB pathway. 
    Sci. Rep. 3, 2568; doi:10.1038/srep02568 (2013)
  • Ishikawa, K., Ito, K., Inoue, J. and Semba, K.
    Cell growth control by stable Rbg2/Gir2 complex formation under amino acid starvation. 
    Genes Cells 18(10), 859-872. (2013)
  • Yamamoto, M., Taguchi, Y., Ito-Kureha, T., Semba, K., Yamaguchi, N. and Inoue J.
    NF-κB non-cell-autonomously regulates cancer stem cell populations in the basal-like breast cancer subtype. 
    Nat. Commun. 4:2299 doi: 10.1038/ncomms3299 (2013) 
    *日本語解説
  • Kojima, A., Akizawa, T., Gohda, J., Ueda, Y. and Inoue. J.
    Partial purification of Lys63 ubiquitinated proteins by using a column switch HPLC method. 
    PEPTIDE SCIENCE 2012 161-164 (2013)

 

2012年

 

  • Ohshima, D., Inoue, J., Ichikawa, K.
    Roles of Spatial Parameters on the Oscillation of Nuclear NF-κB: Computer Simulations of a 3D Spherical Cell. 
    PLoS One 7(10), e46911. (2012)
  • Yamaguchi, N., Yokota, M., Taguchi, Y., Gohda, J. and Inoue, J.
    cIAP1/2 negatively regulate RANKL-induced osteoclastogenesis through the inhibition of NFATc1 expression. 
    Genes Cells 17(12), 971-81. (2012)
  • Shibata, Y., Oyama, M., Kozuka-Hata, H., Han, X., Tanaka, Y., Gohda, J. and Inoue, J.
    p47 negatively regulates IKK activation by inducing the lysosomal degradation of polyubiquitinated NEMO. 
    Nat. Commun3:1061 (2012)
    *日本語解説
  • Hinohara, K., Kobayashi, S., Kanauchi, H., Simizu, S., Nishioka, K., Tsuji, E., Tada, K., Umezawa, K., Mori, M., Ogawa, T., Inoue, J., Tojo, A. and Gotoh, N. 
    ErbB/NF-κB signaling controls mammosphere formation in human breast cancer. 
    Proc. Natl. Acad. Sci. USA 109(17), 6584-9. (2012)
  • Taguchi, Y., Kiga, Y., Gohda, J. and Inoue, J. 
    Identification and characterization of anti-osteoclastogenic peptides derived from the cytoplasmic tail of RANK. 
    J. Bone Miner. Metab. 30(5), 543-53.(2012)
  • Sanada T, Kim M, Mimuro H, Suzuki M, Ogawa M, Oyama A, Ashida H, Kobayashi T, Koyama T, Nagai S, Shibata Y, Gohda J, Inoue JI, Mizushima T, Sasakawa C.
    The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory response.
    Nature 483, 623-626. (2012)
  • Ohba, T., Ariga, Y., Maruyama, T., Truong, N., Inoue, J., and Muta, T.
    Identification of interleukin-1 receptor-associated kinase 1 as a critical component that induces post-transcriptional activation of IκBα.
    FEBS J. 279(2), 211-222. (2012)


2011年

 

  • 秦俊文, 謝琪璇, 蔡冬青, 秋山泰身, 井上純一郎
    shRNA慢病毒質粒的構建技巧.
    中国生物工程雑志. 31(3), 124-127. (2011)
  • Shinzawa, M., Maruyama, T., Qin, J., Akiyama, N., Miyauchi, M., Yanai H., Takami, M., Inoue, J., and Akiyama, T.
    Splenic extramedullary hemopoiesis caused by a dysfunctional mutation in the NF-κB inducing kinase gene.
    Biochem. Biophys. Res. Commun. 414(4), 773-778. (2011)
  • Kanemaru, Y., Momiki, Y., Matsuura, S., Horikawa, T., Gohda, J., Inoue, J., Okamoto, Y., Fujita, F., and Otsuka M.
    An artificial copper complex incorporating a cell-penetrating peptide inhibits NF-κB activation.
    Chem. Pharm. Bull. 59(12), 1555-1558. (2011)
  • Shibata, Y., Tanaka, Y., Gohda, J., and Inoue, J.
    Activation of the IkB kinase complex by HTLV-1 Tax requires cytosolic factors involved in Tax-induced polyubiquitination.
    J. Biochem. 150(6), 679-686. (2011)
  • Ohshima, D., Qin, J., Konno, H., Hirosawa, A., Shiraishi, T., Yanai, H., Shimo, Y., Akiyama, N., Yamashita, T., Nakai, K., Akiyama, T., Inoue, J.
    RANK signaling induces interferon-stimulated genes in the fetal thymic stroma.
    Biochem. Biophys. Res. Commun. 408(4), 530-536. (2011)
  • Mouri, Y., Yano, M., Shinzawa, M., Shimo, Y., Hirota, F., Nishikawa, Y., Nii, T., Kiyonari, H., Abe, T., Uehara, H., Izumi, K., Tamada, K., Chen, L., Penninger, J. M., Inoue, J., Akiyama, T., and Matsumoto, M.
    Lymphotoxin Signal Promotes Thymic Organogenesis by Eliciting RANK Expression in the Embryonic Thymic Stroma.
    J. Immunol186(9), 5047-5057. (2011)
  • Ohno, T., Oboki, K., Kajiwara, N., Tanaka, S., Ikeda, M., Iikura, M., Akiyama, T., Inoue, J., Matsumoto, K., Sudo, K., Azuma, M., Okumura, K., Kamradt, T., Saito, H., and Nakae, S.
    Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage activation.
    PLoS ONE 6(4), e18404. (2011)
  • Shimo, Y., Yanai, H., Ohshima, D., Qin, J., Motegi, H., Maruyama, Y., Hori, S., Inoue, J., and Akiyama, T.
    TRAF6 directs commitment to regulatory T cells in thymocytes.
    Genes Cells 16(4):437-47. (2011)

 

2010年

 

  • Tasaki S, Nagasaki M, Kozuka-Hata H, Semba K, Gotoh N, Hattori S, Inoue J, Yamamoto T, Miyano S, Sugano S, Oyama M.
    Phosphoproteomics-Based Modeling Defines the Regulatory Mechanism Underlying Aberrant EGFR Signaling.
    PLoS One 5(11):e13926. (2010)
  • Motegi, H., Shimo, Y., Akiyama, T., and Inoue, J.
    TRAF6 negatively regulates the Jak1-Erk pathway in interleukin-2 signaling.
    Genes Cells 16(2):179-89. (2010)
  • Ishiguro, A., Akiyama, T., Adachi, H., Inoue, J. and Nakamura Y.
    Therapeutic Potential of Anti-Interleukin-17A Aptamer: Suppression of IL-17A Signaling and Attenuation of Autoimmunity in Mouse Models.
    Arth . Rheu. 63(2):455-66. (2010)
  • Matsumura, T., Oyama, M., Kozuka-Hata, H., Ishikawa, K., Inoue, T., Muta, T., Semba, K., and Inoue, J.
    Identification of BCAP-L as a negative regulator of the TLR signaling-induced production of IL-6 and IL-10 in macrophages by tyrosine phosphoproteomics.
    Biochem. Biophys. Res. Commun. 400(2):265-70. (2010)
  • Yamamoto, M., Ito, T., Shimizu, T., Ishida, T., Semba, K., Watanabe, S., Yamaguchi, N, and Inoue, J.
    Epigenetic alteration of the NF-κB inducing kinase (NIK) gene is involved in enhanced NIK expression in basal-like breast cancer.
    Cancer Sci. 101(11):2391-7. (2010)
  • Tando, T., Ishizaka, A., Watanabe, H., Ito, T., Iida, S., Haraguchi, T., Mizutani, T., Izumi, T., Isobe, T., Akiyama, T., Inoue, J. and Iba, H.
    Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a non-canonical NF-κB pathway.
    J. Biol. Chem. 285(29):21951-60. (2010)
  • Ando, K., Hasegawa, K., Shindo, K., Furusawa, T., Fujino, T., Kikugawa, K., Nakano, H., Takeuchi, O., Akira, S., Akiyama, T., Gohda, J., Inoue, J., and Hayakawa, M.
    Human lactoferrin activates NF-κB through Toll-like receptor 4 (TLR4) pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling.
    FEBS Journal 277(9):2051-66. (2010)

 

2009年

 

  • Nagatake, T., Fukuyama, S., Kim, D.Y., Goda, K., Igarashi, O., Sato, S., Nochi, T., Sagara, H., Yokota, Y., Jetten, A.M., Kaisho, T., Akira, S., Mimuro, H., Sasakawa, C., Fukui, Y., Fujihashi, K., Akiyama, T., Inoue, J., Penninger, J.M., Kunisawa, J., Kiyono, H.
    Id2-, ROR{gamma}t-, and LT{beta}R-independent initiation of lymphoid organogenesis in ocular immunity.
    J Exp Med. 206(11):2351-64. (2009)
  • Yamazaki, K., Gohda, J., Kanayama, A., Miyamoto, Y., Sakurai, H., Yamamoto, M., Akira, S., Hayashi, H., Su, B., and Inoue, J.
    Two Mechanistically and Temporally Distinct NF-κB Activation Pathways in IL-1 Signaling.
    Sci. Signal. 2, ra66. (2009) 
    * [Perspectives] TAK-ling IKK Activation: "Ub" the Judge. Sci. Signal. 3 (105), pe3.(2010)
    [日本語解説]
    [医科研HPでも紹介されています]
  • Ishikawa, K., Akiyama, T., Ito, K., Semba, K., and Inoue, J.
    Independent stabilizations of polysomal Drg1/Dfrp1 complex and non-polysomal Drg2/Dfrp2 complex in mammalian cells.
    Biochem. Biophys. Res. Commun. 18;390(3):552-6. (2009)
  • Taguchi,Y., Gohda, J., Koga,T., Takayanagi, H., and Inoue, J.
    A unique domain in RANK is required for Gab2 and PLCγ2 binding to establish osteoclastogenic signals.
    Genes Cells 14(11):1331-45. (2009)
  • Nishina, T., Yamaguchi, N., Gohda, J., Semba, K. and Inoue, J.
    NIK is involved in constitutive activation of the alternative NF-κB pathway and proliferation of pancreatic cancer cells.
    Biochem. Biophys. Res. Commun. 388(1):96-101. (2009)
  • Matsumura, T., Kawamura-Tsuzuku, J., Yamamoto, T., Semba, K., and Inoue, J.
    TRAF-interacting protein with a forkhead-associated domain B (TIFAB) is a negative regulator of the TRAF6-induced cellular functions.
    J. Biochem. 146(3):375-81. (2009)
  • Yamaguchi, N., Ito, T., Azuma, S., Ito, E., Honma, R., Yanagisawa, Y., Nishikawa, A., Kawamura, M., Imai, J., Watanabe, S., Semba, K.and Inoue, J.
    Constitutive activation of NF-κB is preferentially involved in the proliferation of basal-like subtype breast cancer cell lines.
    Cancer Sci. 100(9):1668-74. (2009)
  • Konno, H., Yamamoto, T., Yamazaki, K., Gohda, J., Akiyama, T., Semba, K., Goto, H., Kato, A, Yujiri, T, Imai, T., Kawaguchi, Y., Su, B., Takeuchi, O., Akira, S., Tsunetsugu-Yokota, Y., & Inoue, J.
    TRAF6 Establishes Innate Immune Responses by Activating NF-κB and IRF7 upon Sensing Cytosolic Viral RNA and DNA.
    PLoS ONE 4(5): e5674. (2009)
  • Oyama, M., Kozuka-Hata, H, Tasaki, S., Semba, K., Hattori, S., Sugano, S., Inoue, J. and Yamamoto, T.
    Temporal perturbation of tyrosine-phosphoproteome dynamics reveals the system-wide regulatory networks.
    Mol. Cell. Proteomics 8(2):226-31. (2009)
  • Yamamoto, T., Yokota, Y., Mitsuki, Y., Mizukoshi, F., Tsuchiya, T., Terahara, K., Inagaki, Y., Yamamoto, N., Kobayashi, K., and Inoue, J.
    Selective transmission of R5 HIV-1 over X4 HIV-1 at the dendritic cell-T cell infectious synapse is determined by the T cell activation state.
    PLos Pathog. 5(1): e1000279. (2009)

 

2008年

 

  • Akiyama T., Shimo Y., Yanai H., Qin J., Ohshima, D., Maruyama Y., Asaumi Y., Kitazawa J., Takayanagi H., Penninger JM., Matsumoto M., Nitta T., Takahama Y., and Inoue J.
    The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.
    Immunity 29(3):423-37. (2008)
    日本語解説(医科研HPへ移動します), 2008.9.29朝日新聞科学面(新しいウィンドウが開きます.)
  • Selvarajoo, K, Takada, Y, Gohda, J., Helmy, M., Akira, S., Tomita, M., Tsuchiya, M., Inoue, J. and Matsuo, K.
    Signaling Flux Redistribution at Toll-like Receptor Pathway Junctions.
    PLoS ONE 3 (10) e3430. (2008)
  • Hikosaka Y., Nitta T., Ohigashi I., Yano K., Ishimaru N., Hayashi Y., Matsumoto M., Matsuo K., Penninger JM., Takayanagi H., Yokota Y., Yamada H., Yosikai Y., Inoue J., Akiyama T., and Takahama Y. 
    The Cytokine RANKL Produced by Positively Selected Thymocytes Fosters Medullary Thymic Epithelial Cells that Express Autoimmune Regulator.
    Immunity 29(3):438-50. (2008)
  • Yang Y.J., Chen W., Carrigan S.O., Chen W-M., Roth K., Akiyama T., Inoue J., Marshall J.S., Berman J.N. and Lin Y-J. 
    TRAF6 specifically contributes to FcεRI-mediated cytokine production but not mast cell degranulation.
    J. Biol. Chem. 14;283(46). (2008)
  • Yamaguchi, N., Oyama T, Ito E, Satoh H, Azuma S, Hayashi M, Shimizu K, Honma R, Yanagisawa Y, Nishikawa A, Kawamura M, Imai J, Ohwada S, Tatsuta K, Inoue J, Semba K, & Watanabe S. 
    NOTCH3 signaling pathway plays crucial roles in proliferation of ErbB2-negative human breast cancer cells.
    Cancer Res. 68, 1881-1888, (2008)
  • Yamaguchi, N., Ito, E., Azuma, S., Honma, R., Yanagisawa, Y., Nishikawa, A., Kawamura, M., Imai, J., Tatsuta, K., Inoue, J., Semba, K., and Watanabe, S. 
    FoxA1 as a lineage-specific oncogene in luminal type breast cancer. 
    Biochem. Biophys. Res. Commun. 365, 711-717, (2008)
  • Miyasaka, T., Morita, M., Ito, K., Suzuki, T., Fukuda, H., Takeda, S., Inoue, J., Semba, K. and Yamamoto, T. 
    Interaction of anti-proliferative protein Tob with the CCR4-NOT deadenylase complex. 
    Cancer Sci. 99, 755-61, (2008)

 

2007年

 

  • Qin, J., Konno, H., Ohshima, D., Yanai, H., Motegi, H., Hirota, F., Matsumoto, M., Takaki, S., Inoue, J., and Akiyama, T. 
    Developmental stage-dependent collaboration between the TRAF6 and lymphotoxin pathways for B-cell follicle organization in secondary lymphoid organs. 
    J. Immunol. 179, 6799-6807, (2007)
  • Ito, E., Honma, R., Yanagisawa, Y., Imai, J., Azuma, S., Oyama, T., Ohwada, S., Akiyama, T., Nomura, N., Inoue, J., Watanabe, S., and Semba, K. 
    Novel clusters of highly expressed genes accompany genomic amplification in breast cancers. 
    FEBS Letter 581, 3909-3914, (2007)
  • Jin Gohda, Masato Irisawa, Yuetsu Tanaka, Shintaro Sato, Kiyoshi Ohtani, Jun-ichi Fujisawa, and Jun-ichiro Inoue. 
    HTLV-1 Tax-induced NFκB activation is independent of Lys-63-linked-type polyubiquitination. 
    Biochem. Biophys. Res. Commun. 357, 225-230, (2007)
  • Inoue, J., Gohda, J., Akiyama, T., and Semba, K. 
    NFkappaB activation in development and progression of cancer. (review) 
    Cancer Sci. 98, 268-274, (2007)
  • Saito A, Nagasaki M, Oyama M, Kozuka-Hata H, Semba K, Sugano S, Yamamoto T, and Miyano S. 
    AYUMS: an algorithm for completely automatic quantitation based on LC-MS/MS proteome data and its application to the analysis of signal transduction. 
    BMC Bioinformatics (2007), accepted.

 

2006年

 

  • Ichikawa D, Funakoshi-Tago M, Aizu-Yokota E, Sonoda Y, Inoue J, Kasahara T. 
    TNF-receptor associated factor 6-deficient fibroblast is sensitive to the TNF-alpha-induced cell death: Involvement of reactive oxygen species.
    Biochem. Biophys. Res. Commun. 351, 93-98, (2006)
  • Takuya Yamamoto, Hiroyuki Miyoshi, Norio Yamamoto, Naoki Yamamoto, Jun-ichiro Inoue, and Yasuko Tsunetsugu-Yokota. 
    Lentivirus vectors expressing short hairpin RNAs against the U3-overlapping region of HIV nef inhibit HIV replication and infectivity in primary macrophages. 
    Blood 108, 3305-3312, (2006)
  • Ito, H., Esashi,E., Akiyama,T., Inoue,J., and Miyajima, A. 
    IL-18 produced by thymic epithelial cells induces development of dendritic cells with CD11b in the fetal thymus. 
    Int. Immunol. 18, 1253-1263, (2006)
  • Miyahara,T., Koyama,H., Miyata,T., Shigematsu,H., Inoue,J., Takato,T., and Nagawa, H. 
    Inflammatory responses involving tumor necrosis factor receptor-associated factor 6 contribute to in-stent lesion formation in a stent implantation model of rabbit carotid artery. 
    J.Vasc.Surg. 43,592-600. (2006)
  • Inoue, J., Gohda, J., and Akiyama, T.
    Characteristics and Biological Functions of TRAF6.
    In “TRAFs” edited by Hao Wu. Landes Bioscience, (2006).
  • Sharma, R.K., Chopra, S., Sharma, S.D., Pande, V., Ramos, M.J., Meguro, K., Inoue, J., and Otsuka, M. 
    Biological evaluation, chelation and molecular modeling studies of novel metal-chelating inhibitors of NF-κB-DNA binding: Structure activity relationship. 
    J. Med. Chem. 49, 3595-3601. (2006)
  • Maezawa, Y., Nakajima, H., Suzuki, K., Tamachi, T., Ikeda, K., Inoue, J., Saito, Y., and Iwamoto, I. 
    Involvement of TNF Receptor-associated Factor (TRAF) 6 in IL-25 Receptor Signaling. 
    J. Immunol. 176, 1013-1018, (2006).

 

2005年

 

  • Takaki, T., Fukasawa, K., Suzuki-Takahashi, I., Semba, K., Kitagawa, M., Taya, Y., and Hirai H. 
    Preferences in Phosphorylation Sites in the Retinoblastoma Protein between D-Type Cyclin-Dependent Kinases, Cdk4 and Cdk6 In Vitro. 
    J. Biochem. 137, 381-386, (2005)
  • Noguchi, T., Takeda, K., Matsuzawa, A., Saegusa, K., Nakano, H., Gohda, J., Inoue, J., and Ichijo, H. 
    Recruitment of TRAF family proteins to The ASK1 signalosome is essential for oxidative stress-induced cell death. 
    J. Biol. Chem. 280, 37033-37040, (2005).
  • Inoue, J., Yagi, S., Ishikawa, K., Azuma, S., Ikawa, S., and Semba, K. 
    Identification and characterization of Xenopus laevis homologs of mammalian TRAF6 and its binding protein TIFA. 
    Gene 358, 53-59, (2005)
  • Akiyama, T., Maeda, S., Yamane, S., Ogino, K., Kasai, M., Kajiura, F., Matsumoto, M., and Inoue, J. 
    Dependence of Self-tolerance on TRAF6-directed Development of Thymic Stroma. 
    Science 308, 248-251, (2005)
    *Research Highlight “TRAF6 distributes tolerance” in Nature Reviews Immunology5, 269. (2005)
  • Gohda, J., Akiyama, T., Koga, T., Takayanagi, H., Tanaka, S., and Inoue, J. 
    RANK-mediated amplification of TRAF6 signaling leads to NFATc1 induction during osteoclastogenesis 
    EMBO J.24, 790-799, (2005)
  • Ishikawa, K., Azuma, S., Ikawa, S., Semba, K., and Inoue, J. 
    Identification of DRG family regulatory proteins (DFRPs): Specific regulation of DRG1 and DRG2. 
    Genes Cells 10, 139-150, (2005).
  • Okochi, K., Suzuki, T., Inoue, J., Matsuda. S. and Yamamoto, T. 
    Interaction of antiproliferative protein Tob with poly(A)-binding protein and inducible poly(A)-binding protein: Implication of Tob in translational control. 
    Genes Cells 10, 151-163, (2005).
  • Sharma, R.K., Pande, V., Ramos, M.J., Rajor, H.K.,Chopra, S., Meguro, K., Inoue, J., Otsuka, M.
    Inhibitory activity of polyhydroxycarboxylate chelators against recombinant NF-κB p50 Protein-DNA binding. 
    Bioorg. Chem. 33, 67-81, (2005)

 

2004年

 

  • Sharma, R.K., Otsuka, M., Pande, V., Inoue, J., and Joao Ramos, M. 
    Evans Blue is an inhibitor of nuclear factor-kappa B (NF-kappaB)-DNA binding. 
    Bioorg. Med. Chem Lett. 14, 6123-6127. (2004)
  • Yeiser, E.C., Rutkoski, N.J., Naito, A., Inoue, J., and Carter, B.D. 
    Neurotrophin signaling through the p75 receptor is deficient in traf6-/-mice. 
    J. Neurosci. 24, 10521-10529. (2004)
  • Ea, C.-K., Sun, L., Inoue, J., and Chen, Z.J. 
    TIFA activates IκB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6. 
    Proc. Natl. Acad. Sci. USA 101, 15318-15323, (2004)
  • Kawai, T., Sato, S., Ishii, K.J., Coban, C., Hemmi, H., Yamamoto, M., Terai, K., Matsuda, M., Inoue, J., Uematsu, S., Takeuchi, O., and Akira, S. 
    Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. 
    Nat. Immunol. 10, 1061-1068, (2004).
  • Ikeda, F., Nishimura, R., Matsubara, T., Tanaka, S., Inoue, J., Reddy, S.V., Hata, K., Yamashita, K., Hiraga, T., Watanabe, T., Kukita, T., Yoshioka, K., Rao, A., and Yoneda, T. 
    Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation. 
    J. Clin. Invest. 114, 475-484, (2004)
  • Gohda, J., Matsumura, T., and Inoue, J. 
    Cutting Edge: TNF Receptor-Associated Factor (TRAF) 6 is Essential for Myeloid Differentiation Factor (MyD) 88-Dependent Pathway but Not Toll/IL-1 Receptor Domain-Containing Adaptor Inducing IFN-β(TRIF)-Dependent Pathway in Toll-like Receptor Signaling. 
    J. Immunol.173, 2913-2917, (2004)
  • Matsumura T, Semba K, Azuma S, Ikawa S, Gohda J, Akiyama T, Inoue J. 
    TIFAB inhibits TIFA, TRAF-interacting protein with a forkhead-associated domain. 
    Biochem. Biophys. Res. Commun.317, 230-234, (2004).
  • Matsumura T, Hayashi H, Takii T, Thorn CF, Whitehead AS, Inoue J, Onozaki K. 
    TGFbeta down-regulates IL-1alpha-induced TLR2 expression in murine hepatocytes. 
    J. Leukoc. Biol. 75, 1056-1061, (2004).
  • Ohazama, A., Courtney, J-M., Naito, A., Inoue, J., Tanaka, S. and Sharpe, P.T. 
    Traf6 is essential for murine tooth cusp morphogenesis. 
    Development Dynamics 229, 131-135 (2004)

 

2003年

 

  • Miyamoto Y, Kanayama A, Inoue J, Konishi YS, Shimizu M. 
    Taurine is involved in oxidation of IkappaB alpha at Met45: N-halogenated taurine and anti-inflammatory action. 
    Adv. Exp. Med. Biol. 526, 373-380 (2003)
  • Pande, V., Sharma, R. K., Inoue, J., Otsuka, M., and Ramos, M. J. 
    A molecular modeling study of inhibitors of nuclear factor kappa-B (p50)-DNA binding. 
    J. Comput-Aided Mol. Des. 17, 825-836, (2003).
  • Luftig, M., Prinarakis, E., Yasui, T., Tsichritzis, T., Cahir-McFarland, E., Inoue, J., Nakano, H., Mak, T.W., Yeh, W.-C., Li, X/, Akira, S., Suzuki, N., Suzuki, S., Mosialos, G. and Kieff, E. 
    Epstein-Barr virus latent membrane protein 1 activation of NFκB through IRAK1 and TRAF6. 
    Proc. Natl. Acad. Sci. USA 100, 15595-15600. (2003)
  • Ito, E., Honma, R., Imai, J., Azuma, S., Kanno, T., Mori, S., Yoshie, O., Nishio, J., Iwasaki, H., Yoshida, K., et al. 
    A Tetraspanin-Family Protein, T-Cell Acute Lymphoblastic Leukemia-Associated Antigen 1, Is Induced by the Ewing's Sarcoma-Wilms' Tumor 1 Fusion Protein of Desmoplastic Small Round-Cell Tumor. 
    Am. J. Pathol. 163, 2165-2172. (2003)
  • Ishikawa, K., Azuma, S., Ikawa, S., Morishita, Y., Gohda, J., Akiyama, T., Semba, K. and Inoue, J. 
    Cloning and characterization of Xenopus laevis drg2, a member of the developmentally regulated GTP-binding protein subfamily. 
    Gene 322, 105-112 (2003)
  • Gohda, J., Inoue J. and Umezawa K. 
    Down-regulation of TNF receptors by conophylline in human T-cell Leukemia cells.
    Int. J. Oncology 23, 1373-1379 (2003)
  • Niu, Y., Murata, T., Watanabe, K., Kawakami, K., Yoshimura, A., Inoue, J., Puri, R.K., and Kobayashi. N. 
    MIP-T3 associates with IL-13RK1 and suppresses STAT6 activation in response to IL-13 stimulation. 
    FEBS Letter 550, 139-143 (2003)
  • Tanaka S, Nakamura I, Inoue J, Oda H, Nakamura K. 
    Signal transduction pathways regulating osteoclast differentiation and function. 
    J Bone Miner Metab. 21, 123-33. (2003)
  • Yumiko Matsuzawa-Watanabe, Jun-ichiro Inoue, and Kentaro Semba. 
    Transcriptional activity of testis-determining factor SRY is modulated by the Wilms' tumor 1 gene product, WT1. 
    Oncogene 22, 7900-7904 (2003)
  • Yukinori Minoshima, Toshiyuki Kawashima, Koichi Hirose, Yukio Tonozuka, Aie Kawajiri, Ying Chun Bao, Xingming Deng, Masaaki Tatsuka, Shuh Narumiya, W. Stratford May Jr., Tetsuya Nosaka, Kentaro Semba, Takafumi Inoue, Takaya Satoh, Masaki Inagaki, and Toshio Kitamura. 
    Phosphorylation by Aurora B Converts MgcRacGAP to a RhoGAP during Cytokinesis.
    Developmental Cell 4, 549-560, (2003).
  • Matsumura, T., Degawa, T., Takii, T., Hayashi, H., Okamoto, T., Inoue, J. and Onozaki, K. 
    TRAF6-NF-κB pathway is essential for interleukin-1-induced TLR2 expression and its functional response to TLR2 ligand in murine hepatocytes.
    Immunology 109, 127-136. (2003)
  • Ohsugi M, Nishizumi NT, Shiroguchi K, Toyoshima YY, Inoue J, and Yamamoto T.
    Cdc2-mediated phosphorylation of chromokinesin Kid controls its distribution to spindle and chromosomes. 
    EMBO J. 22, 2091-2103. (2003)
  • Takatsuna, H., Kato, H., Gohda, J., Akiyama, T., Moriya, A., Okamoto, Y., Yamagata, Y., Otsuka, M., Umezawa, K., Semba, K., and Inoue, J. 
    Identification of TIFA as an adapter protein that links TRAF6 to IRAK-1 in IL-1 receptor signaling.
    J. Biol. Chem. 278, 12144-12150. (2003)
  • Kittaka, A., Kuze, T., Sarai, A., Takatama, H., Miyasaka, T., Inoue, J. and Ishii, S. 
    Synthesis of oligonucleotides with 6-formyl-2’-O-methyluridine and thermal stability of their duplexes. 
    Heterocycles 59, 207-215 (2003).
  • Gohda, J., Nomura, Y., Suzuki, H., Arai, H., Akiyama, T., and Inoue, J. 
    Elimination of the vertabrate E. coli Ras-like protein homologue leads to cell cycle arrest at G1 phase and apoptosis. 
    Oncogene 22, 1340-1348. (2003)

 

2002年

 

  • Takayanagi, H., Kim, S., Koga, T., Nishina, H., Isshiki, M., Yoshida, H., Saiura A., Isobe, M., Yokochi, T., Inoue, J., Wagner, E.F., Mak, T.W., Kodama T., and Taniguchi, T. 
    Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. 
    Dev. Cell 3, 889-901. (2002)
  • Yoshida, H., Naito, A., Inoue, J., Satoh, M., Santee-Cooper, SM., Ware, CF., Togawa, A., Nishikawa, S., and Nishikawa, SI. 
    Different cytokines induce surface lymphotoxin-ab on IL-7 receptor-a cells that differentially engender lymph nodes and Peyer's patches. 
    Immunity 17, 823-833. (2002)
  • Ariga. A., Namekawa, J., Matsumoto, N., Inoue, J., and Umezawa, K. 
    Inhibition of TNF-α-induced nuclear translocation and activation of NF-κB by dehydroxymethyl-epoxyquinomicin. 
    J Biol. Chem. 277, 24625-24630 (2002)
  • Nishioka, E., Tanaka, T., Yoshida, H., Matsumura, K., Nishikawa, S., Naito, A., Inoue, J., Funasaka, Y., Ichihashi, M., Miyasaka, M. and Nishikawa, S. 
    MAdCAM-1 plays an unexpected role in the development of mouse guard hair. 
    J. Invest. Dermatol. 119, 632-638 (2002)
  • Naito, A., Yoshida H., Nishioka E, Satoh M., Azuma S., Yamamoto T., Nishikawa S. and Inoue J. 
    TRAF6-deficient mice display hypohidrotic ectodermal dysplasia. 
    Proc. Natl. Acad. Sci. USA 99, 8766-8771. (2002)
  • Kanayama, A., Inoue, J., Sugita-Konishi, Y., Shimizu, M., and Miyamoto, Y. 
    Taurine is involved in methionine 45 oxidation of IκBα and consequent inhibition of NFκB activation. 
    J. Biol. Chem. 277, 24049-24056 (2002)

 

2001年

 

  • Kawai, T., Takeuchi, O., Fujita, T., Inoue, J., Muhlradt, P. F., Sato, S., Hoshino, K., and Akira S. 
    Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. 
    J. Immunol. 167, 5887-5894. (2001)
  • Akiyama, T., Gohda, J., Shibata, S., Nomura, Y., Azuma, S., Ohmori, Y., Sugano, S., Arai. H., Yamamoto, T., and Inoue, J. 
    Mammalian homologue of E. coli Ras-like GTPase (ERA) is a possible apoptosis regulator with RNA binding activity. 
    Genes Cells 6, 987-1001. (2001)
  • Wang, C., Deng, Li., Hong, M., Akkaraju, G.R., Inoue, J, and Chen, Z.J. 
    TAK1 is a ubiquitin-dependent kinase of MKK and IKK. 
    Nature 412, 346-351. (2001)
  • Kaji, K., Katogi, R., Azuma, Y., Naito, A., Inoue, J., and Kudo, A. 
    TNFα-induced osteoclastgenesis requires TRAF6. 
    J. Bone Miner. Res. 16(9), 1593-1599. (2001)
  • Kittaka, A., Takayama, H., Kurihara, M., Horii, C., Tanaka, H.Y., Miyasaka, T., and Inoue, J. 
    DNA Sequence Recognition by NFκB p50 Homodimer: Strict and Obscure Recognition Sites in the Binding Sequence. 
    Nucleosides Nucleotides and Nucleic Acids 20 (4-7), 669-672. (2001)
  • Kobayashi N., Kadono Y., Naito A., Matsumoto K., Yamamoto T., Tanaka S., and Inoue J. 
    Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis. 
    EMBO J. 20, 1271-1280, (2001).
  • Nakazawa, T., Komai, S., Tezuka, T., Hisatsune, C., Umemori, H., Semba, K., Mishina, M., Manabe, T., and Yamamoto, T. 
    Characterization of Fyn-mediated tyrosine phosphorylation sites on GluR epsilon 2 (NR2B) subunit of the N-methyl-D-aspartate receptor. 
    J Biol Chem. 276, 693-699. (2001)
  • Yamochi, T., Semba, K., Tsuji, K., Mizumoto, K., Sato, H., Matsuura, Y., Nishimoto, I., and Matsuoka, M. 
    ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3). 
    Eur J Biochem. 268, 6076-6082. (2001)

 

2000年

 

  • Hatzoglou, A., Roussel, J., Bourgeade, M.-F., Rogier, E., Madry, C., Inoue, J., Devergne, O., and Tsapis, A. 
    Tumor necrosis factor receptor family member BCMA ( B-cell maturation) associates with TRAF1, TRAF2 and TRAF3 and activates NF-κB, Elk-1 and c-Jun N-terminal kinase. 
    J. Immunol. 165. 1322-1330. (2000)
  • Sharma, K. M., Garg, B. S., Kurosaki, H., Goto, M., Otsuka, M, Yamamoto, T., and Inoue, J. 
    Aurine Tricarboxylic Acid, a potent metal-chelating inhibitor of NFκB-DNA binding.
    Bioorg. Med. Chem. 8. 1819-1823. (2000)
  • Matsumoto, N., Ariga, A., To-e, S., Agata, N., Hirano, S., Inoue, J., and Umezawa K. 
    Synthesis of NF-kB activation inhibitors derived from epoxyquinomicin C. 
    Bioorg. Med. Chem. Lett. 10,865-869. (2000)
  • Inoue, J., Ishida, T., Tsukamoto, N., Kobayashi, N., Naito, A., Azuma, S., and Yamamoto, T. 
    Tumor necrosis factor receptor-associated factor (TRAF) family: adapter proteins that mediate cytokine signaling. 
    Exp. Cell Res. 254 14-24. (2000)
  • Matsuoka, M., Matsuura, Y., Semba, K., and Nishimoto, I. 
    Molecular cloning of a cyclin-like protein associated with cyclin- dependent kinase 3 (cdk 3) in vivo. 
    Biochem Biophys Res Commun. 273, 442-447. (2000)
  • Kim, J. M., Hong, Y., Semba, K., and Kim, S. 
    Physical and functional interaction between the HCMV IE2 protein and the Wilms' tumor suppressor WT1. 
    Biochem Biophys Res Commun267, 59-63. (2000)

 

1999年

 

  • Kittaka, A., Takayama, H., Horii, C., Kuze, T., Tanaka, H., Nakamura, K., Miyasaka, T., and Inoue, J. 
    Synthesis of oligonucleotides containing the oxidatively modified κB site: unique binding affinity to the NFκB p50 homodimer. 
    Nucleic Acids Symposium Series 42, 33-34. (1999)
  • Ihata, A., Watabe, S., Sasaki, S., Shirai, A., Fukushima, J., Hamajima, J., Inoue, J., and Okuda, K. 
    Immunomodulatory effect of a plasmid expressing CD40 ligand on DNA vaccination against Human Immunodeficiency Virus type-1. 
    Immunology 98, 436-442. (1999)
  • Shimada, T., Kawai, T., Takeda, K., Matsumoto, M., Inoue, J., Tatsumi, Y., Kanamura, A., and Akira, S. 
    IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IκBα kinases. 
    Int. Immunol. 11, 1357-1362. (1999)
  • Sakurai, A., Hara, S., Okano, N., Kondo, Y., Inoue, J. and Imura, N. 
    Regulatory role of metallothionein in NF-κB activation. 
    FEBS Lett. 455, 55-58. (1999)
  • Naito, A., Azuma, S., Tanaka, S., Miyazaki, T., Takaki, S., Takatsu, K., Nakao, K., Nakamura, K., Katsuki, M., Yamamoto, T. and Inoue, J. 
    Severe osteopetrosis, defective interleukin-1 signaling and lymph node organogenesis in TRAF6-deficient mice. 
    Genes Cells 4, 353-362. (1999)
  • Ninomiya-Tsuji, J., Kishimoto, K., Inoue, J., Cao, Z. and Matsumoto, K. 
    TAK1 MAPKKK linking to TRAF6 to the NIK-IκB kinase cascade in the IL-1 signaling pathway. 
    Nature 398, 252-256. (1999)
  • Kittaka, A., Horii, C., Kuze, T., Asakura, T., Ito, K., Nakamura, T. K., Miyasaka, T. and Inoue, J. 
    Introduction of 5-Formyl-2'-deoxyuridine into a κB site: Critical discrimination of a base structure in major groove by NFκB p50 homodimer. 
    Synlett. 10, 869-872 (1999).
  • Tsukamoto, N., Kobayashi, N., Azuma, S., Yamamoto, T and Inoue, J. 
    Two differently regulated NFκB activation pathways triggered by the cytoplasmic tail of CD40. 
    Proc. Natl. Acad. Sci. USA 96, 1234-1239. (1999)
  • Osaki, E., Nishina, Y., Inazawa, J., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Ohsugi, M., Tezuka, T., Yoshida, M., and Semba, K. (1999). 
    Identification of a novel Sry-related gene and its germ cell-specific expression. 
    Nucleic Acids Res 27, 2503-2510.

 

1998

 

  • Li, T., Narhi, L.O., Wen, J., Philo, J.S., Sitney, K., Inoue, J., Yamamoto, T. and Arakawa, T. 
    Interactions between NFκB and its inhibitor IκB: Biophysical characterization of a NFκB/IκBα complex. 
    J. Protein Chem. 17, 757-763. (1998)
  • Yoshimoto, T., Nagase, H., Yoneto, T., Inoue, J. and Nariuchi, H. 
    Interleukin-12 expression in B cells by transformation with Epstein-Barr virus. 
    Biochem. Biophy. Res. Commun. 252, 556-560. (1998)
  • Kittaka, A., Kuze, T., Asakura, T., Ito, K., Miyasaka, T., and Inoue, J. 
    Oligonucleotides bearing 5-formyl-2'-O-methyluridine: Selective binding affinity to the NF-κB (p50)2 homo-amd p50/p65 heterodimers. 
    Bioorg. Med. Chem. Lett. 8, 3207-3210. (1998)
  • Suginaka, R., Izui, R., Inoue, J., Muraoka, Y., Yamaguchi, K., Otsuka, M., and Umezawa, K. 
    Induction of apoptosis in human pancreatic carcinoma cells by a synthetic bleomycin-like ligand. 
    Jpn. J. Cancer Res. 89, 947-953. (1998)
  • Kimura, H., Inukai, Y., Takii, T., Furutani, Y., Shibata, Y., Hayashi, H., Sakurada, S., Okamoto, T., Inoue, J., Oomoto, Y. and Onozaki, K. 
    Molecular analysis of constitutive IL-1α gene expression in human melanoma cells: Autocrine stimulation through NF-κB activation by endogenous IL-1α. 
    Cytokine 10, 872-879. (1998)
  • Kashiwada, M., Shirakata, Y., Inoue, J., Nakano, H., Okazaki, K., Okumura, K., Yamamoto, T., Nagaoka, H and Takemori, T. 
    Tumor necrosis factor receptor-associated factor 6 (TRAF6) stimulates extracellular signal-regulated kinase (ERK) activity in CD signaling along Ras-independent pathway. 
    J. Exp. Med. 187, 237-244. (1998)
  • Suzuki, K., Tsuchida, J., Yamamoto, T. and Inoue, J. 
    Identification and expression of the Xenopus homolog of mammalian p100-NFκB2.
    Gene 206, 1-9. (1998)
  • Mizushima, S., Fujita, M., Ishida, T., Azuma, S., Kato, K., Hirai, M., Otsuka, M., Yamamoto, T. and Inoue, J. 
    Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5). 
    Gene 207, 135-140. (1998)
  • Horie, R., Aizawa, S., Nagai, M., Ito, K., Ishida, T., Inoue, J. and Watanabe, T. 
    A novel domain in the CD30 cytoplasmic tail mediates NFκB activation. 
    Int. Immunol. 10, 203-210. (1998)
  • Hogan, M and Akiyama, T. 
    "Triple helix strategies and progress" in Antisense Research and Application: Handbook of Experimental Pharmacology, S. T. Crooke, ed., Springer-Verlag, Heidelberg, vol 131, pp. 561-530 (1998).

 

1997

 

  • Yoshimoto, T., Nagase, H., Ishida, T., Inoue J. and Nariuchi, H. 
    Induction of Interleukin-12 p40 transcript by CD40 ligation via activation of Nuclear Factor-κB. 
    Eur. J. Immunol. 27, 3461-3470. (1997)
  • Baba, M., Kikuchi, Y., Mori, S., Kimoto, H., Inui, S., Sakaguchi, N., Inoue, J., Yamamoto, T., Takemori, T., Howard, M. and Takatsu, K. 
    Mouse germinal center B cells with the xid mutation retain responsiveness to anti-mouse CD40 antibodies but diminish IL-5 responsiveness. 
    Int. Immunol. 9, 1463-1373. (1997)
  • Sowa, Y., Shiio, Y., Fujita, T., Matsumoto, T., Okuyama, Y., Kato, D., Inoue, J., Sawada, J., Goto, M., Watanabe, H., Handa, H. and Sakai, T. 
    Retinoblastoma binding factor 1 site in the core promoter of the human Rb gene is activated by hGABP/EFTF1. 
    Cancer Research 57, 3145-3148. (1997)
  • Nishiyama-Fujimoto, A., Ishii, S., Matsuda, S., Inoue, J. and Yamamoto, T. 
    A novel zinc finger proteins Finb is a transcriptional activator and localized in nuclear bodies. 
    Gene 195, 267-275. (1997)
  • Aizawa, S., Nakano, H., Ishida, T., Horie, R., Nagai, M., Yagita H., Okumura, K., Inoue, J. and Watanabe, T.
    TRAF5 and TRAF2 are involved in CD30 mediated NFκB activation. 
    J. Biol. Chem. 272, 2042-2045. (1997)
  • Otsuka, M., Fujita, M., Sugiura, Y., Yamamoto, T., Inoue, J., Maekawa, T. and Ishii, S.
    Synthetic inhibitors of regulatory proteins involved in the signaling pathways of the replication of human immunodeficiency virus 1. 
    Bioorg. Med. Chem.5, 205-215. (1997)
  • Sakamoto, Y., Yoshida, M., Semba, K., and Hunter, T. 
    Inhibition of the DNA-binding and transcriptional repression activity of the Wilms' tumor gene product, WT1, by cAMP-dependent protein kinase- mediated phosphorylation of Ser-365 and Ser-393 in the zinc finger domain. 
    Oncogene 15, 2001-2012. (1997)
  • Kuramochi, S., Moriguchi, T., Kuida, K., Endo, J., Semba, K., Nishida, E., and Karasuyama, H. 
    LOK is a novel mouse STE20-like protein kinase that is expressed predominantly in lymphocytes. 
    J Biol Chem. 272, 22679-22684. (1997)
  • Moriyama, M., Yamochi, T., Semba, K., Akiyama, T., and Mori, S. 
    BCL-6 is phosphorylated at multiple sites in its serine- and proline- clustered region by mitogen-activated protein kinase (MAPK) in vivo. 
    Oncogene 14, 2465-2474. (1997)
  • Ojwang, J. O., Mustain, S. D., Marshall, H. B., Rao, T. S., Chaudhary, N., Walker, D. A., Hogan, M. E., Akiyama, T., Revankar, G. R., Peyman, A., Uhlmann, E., and Rando, R. F. 
    Modified antisense oligonucleotides directed against tumor necrosis factor receptor type I inhibit tumor necrosis factor α-mediated functions. 
    Biochemistry 36, 6033-6045. (1997)
  • Akiyama, T. and Hogan, M.E. 
    Structural analysis of DNA bending induced by ththered triple helix forming oligonucleotides. 
    Biochemistry 36, 2307-2315. (1997)
  • Ojwang, J. O., Lewis, A. F., Revankar, G. R., Walker, D., Akiyama. T., Hogan, M. E., and Rando, R. F. 
    Sequence-specific inhibition of the tumor necrosis factor-α receptor I gene by oligodeoxynucleotides containing N7 modified 2’-deoxyguanosine. 
    Antisense Nucleic Acid Drug Dev. 7, 447-459. (1997)

 

1996

 

  • Ishida, T., Mizushima, S., Azuma, S., Kobayashi, N., Tojo, T., Suzuki, K., Aizawa, S., Watanabe, T., Mosialos, G., Kieff, E., Yamamoto, T. and Inoue, J. 
    Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region. 
    J. Biol. Chem. 271, 28745-28748. (1996)
  • Horie, R., Ito, K., Tatewaki, M., Nagai, M., Aizawa, S., Higashihara, M., Ishida, T. Inoue, J., Takizawa, H. and Watanabe, T. 
    A variant CD30 protein lacking extracellular and transmembrane domains is induced in HL-60 by tetradecanoylphorbol acetate (TPA) and is expressed in alveolar macrophages. 
    Blood 88, 2422-2432. (1996)
  • Ishida, T., Tojo, T., Aoki, T., Kobayashi, N., Ohishi, T., Watanabe, T., Yamamoto, T. and Inoue, J. 
    TRAF5, a novel tumor necrosis factor receptor-associated factor family protien, mediates CD40 signaling. 
    Proc. Natl. Acad. Sci. USA 93, 9437-9442. (1996)
  • Uchiumi, F., Maruta, H., Inoue, J., Yamamoto, T. and Tanuma, S. 
    Inhibitory effect of tannic acid on human immunodeficiency virus promoter activity induced by 12-o-tetra decanoylphorbol-13-acetate in Jurkat T-cells. 
    Biochem. Biophys. Res. Commun. 220, 411-417. (1996)
  • Hirano, M., Osada, S., Aoki, T., Hirai, S., Hosaka, M., Inoue, J. and Ohno, S. 
    MEK kinase is involved in TNFα-induced NFκB activation and degradation of IκBα. 
    J. Biol. Chem. 271, 13234-13238. (1996)
  • Aoki,T., Sano,Y., Yamamoto,T. and Inoue, J. 
    The ankyrin repeats but not the PEST-like sequences are required for signal dependent degradation of IκBα. 
    Oncogene 12, 1159-1164. (1996)
  • Shiio, Y., Sawada, J., Handa, H., Yamamoto, T. and Inoue, J. 
    Activation of the retinoblastoma gene expression by Bcl-3: Implication for muscle cell differentiation. 
    Oncogene 12, 1837-1845. (1996)
  • Tokai, N., Fujimoto-Nishiyama, A., Toyoshima, Y., Yonemura, S., Tsukita, S., Inoue, J. and Yamamoto, T. 
    Kid, a novel Kinesin-like DNA binding protein, is localized to chromosomes and the mitotic spiindles. 
    EMBO J. 15, 457-467. (1996)
  • Semba, K., Saito-Ueno, R., Takayama, G., and Kondo, M. 
    cDNA cloning and its pronephros-specific expression of the Wilms' tumor suppressor gene, WT1, from Xenopus laevis
    Gene 175, 167-172. (1996)
  • Kondo, M., Semba, K., Shiokawa, K., and Yamamoto, T. 
    Molecular cloning of Xenopus activin type I receptor and the analysis of its expression during embryogenesis. 
    Biochem Biophys Res Commun. 218, 549-555. (1996)
  • Akiyama, T. and Hogan, M. E. Microscopic DNA flexibility analysis. 
    Probing the base composition and ion dependence of minor groove compression with an artificial DNA bending agent. 
    J. Biol. Chem. 271, 29126-29135. (1996)
  • Akiyama, T. and Hogan, M.E. 
    The design of an agent to bend DNA. 
    Proc. Natl. Acad. Sci USA 93, 12122-12127. (1996)

 

1995

 

  • Satake, H., Suzuki, K., Aoki, T., Otsuka, M., Sugiura, Y., Yamamoto, T. and Inoue, J. 
    Cupric ion blocks NFκB activation through inhibiting the signal-induced phosphorylation of IκBα. 
    Biochem. Biophys. Res. Commun. 216, 568-573. (1995)
  • Suzuki, K., Yamamoto, T. and Inoue, J. 
    Molecular cloning of cDNA encoding the Xenopus homologue of mammalian RelB. 
    Nuc. Acids Res.23, 4664-4669. (1995)
  • Ishida, T., Kobayashi, N., Tojo, T., Ishida, S., Yamamoto, T. and Inoue, J. 
    CD40 signaling-mediated induction of Bcl-xL, Cdk4 and Cdk6: Implication of their co-operation in selective B cell growth. 
    J. Immunol. 155, 5527-5535. (1995)
  • Otsuka, M., Fujita, M., Aoki, T., Sugiura, Y., Ishii, S., Yamamoto, T., and Inoue, J. 
    Novel zinc chelators with dual activity in the inhibition of the κB site binding proteins, HIV-EP1 and NFκB. 
    J. Med. Chem. 38, 3264-3270. (1995)
  • Shiio, Y., Itoh, M. and Inoue, J. 
    Epitope tagging. 
    Meth. Enzymol. 254, 497-502. (1995)
  • Hohashi, N., Hayashi, T., Fusaki, N., Takeuchi, M., Higurashi, M., Okamoto, T., Semba, K., and Yamamoto, T. 
    The protein tyrosine kinase Fyn activates transcription from the HIV promoter via activation of NF kappa B-like DNA-binding proteins. 
    Int Immunol7, 1851-1859. (1995)
  • Miyao, T., Takakura, Y., Akiyama, T., Yoneda, F., Sezaki, H., and Hashida, M. 
    Stability and Pharmacokinetics Characterization of Oligonucleotides Modified at Terminal Linkage in Mice. 
    Antisense Research and Development 5, 115-121. (1995)

 

1994

 

  • Otsuka, M., Fujita, M., Aoki, T., Sugiura, Y., Ishii, S., Yamamoto, T., and Inoue, J. 
    Novel zinc chelators which inhibit the binding of HIV-EP1 (HIV enhancer binding protein) to NFκB recognition sequence. 
    J. Med. Chem. 37, 4267-4269. (1994)
  • Hirai, H., Suzuki, T., Fujisawa, J., Inoue, J. and Yoshida, M. 
    Tax protein of human T cell leukemia virus type 1 (HTLV-1) binds to the ankyrin motifs of IκB and induces nuclear translocation of NFκB proteins for transcriptional activation. 
    Proc. Natl. Acad. Sci. USA 91, 3584-3588. (1994)
  • Fusaki, N., Semba, K., Katagiri, T., Suzuki, G., Matsuda, S., and Yamamoto, T. 
    Characterization of p59fyn-mediated signal transduction on T cell activation. 
    Int Immunol. 6, 1245-1255. (1994)

 

1993

 

  • Verma, I.M., Kerr, L.D., Inoue, J. and Ransone, L.J. 
    Nuclear oncoproteins target of signal transduction.
    In "Growth factors in perinatal development", R.C. Tsang, J.A. Lemmons and W.F. Balistreri, eds. (Raven Press, Ltd., NY), pp.91-100. (no volume number) (1993).
  • Inoue, J., Takahara, T., Akizawa, T. and Hino, O. 
    Bcl-3, a member of the IκB proteins, has distinct specificity towards Rel family of proteins. 
    Oncogene 8, 2067-2073. (1993)
  • Nakamura, Y., Akiyama, T., Bessho, K., and Yoneda, F. 
    Convenient Synthesis of Oligonucleotide Linked to 5-Deazaflavin Coenzyme Models at 3'-End. Incorporation of 5-Deazaflavin to Controlled Pore Glass (CPG) Support. 
    Chem. Pharm. Bull. 41, 1315-1317. (1993)
  • Nakamura, Y, Akiyama, T., Yoneda, Y., Tanaka, K, and Yoneda, F. 
    Redox Potential of Oligonucleotide Linked to 5-Deazaflavin Coenzyme Model. Detection of Hybrid Formation by Cyclic Voltammometry. 
    Chem. Pharm. Bull. 41 778-780. (1993)

 

1992

 

  • Kerr, L.D., Inoue, J. and Verma, I.M. 
    Signal transduction: the nuclear target. 
    Current Opinion in Cell Biology 4(3), 496-501. (1992)
  • Verma, I.M., Inoue, J., Kerr, L.D., Ofir, R. and Ransone, L.J. 
    Oncogenes as transcription factors: Implications for signal transduction. 
    In "Comparative molecular carcinogenesis", Klein-Szanto, A., Anderson, M., Barret, J.C. and Slaga, T.J., eds. (John Wiley & Sons, Inc. NY), p41- 59. (1992)
  • Inoue, J., Kerr, L.D., Rashid, D., Davis, N., Bose, Jr., H.R. and Verma, I.M. 
    Direct association of pp40/IκBβ with rel/NFκB proteins: Role of ankyrin repeats in the inhibition of DNA binding activity. 
    Proc. Natl. Acad. Sci. USA 89, 4333-4337. (1992)
  • Inoue, J., Kerr, L.D., Kakizuka, A. and Verma, I.M. 
    IκBγ, a 70kd protein, identical to the C terminal half of p110 NFκB: a new member of the IκB family. 
    Cell 68, 1109-1120. (1992)
  • Akiyama, T., Simeno, F., Murakami, M., and Yoneda, F. 
    Flavin-6-carboxylic Acids as Novel and Simple Flavoenzyme Models. Nonenzymatic Stabilization of the Flavin Semiquinone Radical and the 4a-Hydroperoxyflavin by Intramolecular Hydrogen Bonding. 
    J. Am. Chem.Soc. 114, 6613-6620 (1992).
  • Eikyu, Y., Nakamura, Y., Akiyama, T., Yoneda, F., Tanaka, K., and Fuji, K. 
    Hybridization of Oligodeoxynucleotide with Redox Coenzyme Model: Synthesis and Properties of Thymidine Decamers Covalently Linked to 5-Deazaflavin. 
    Chem. Pharm. Bull. 40, 291-293 (1992).

 

1991

 

  • Yoshida, M., Inoue, J. and Fujisawa, J. 
    Positive and negative regulation of human T cell leukemia virus type 1 gene expression and replicaion: Function of the rex gene. 
    In "The human Retrovirus", Gallo, R.C. and Jay, G., eds. (Academic Press, Inc)p3-20 (1991).
  • Inoue. J., Itoh, M., Akizawa, T., Toyoshima, H. and Yoshida, M. 
    HTLV-1 rex protein accumulates unspliced RNA in the nucleus as well as in cytoplasm. 
    Oncogenes 6, 1753-1757. (1991)
  • Kerr, L.D., Inoue, J., Davis, N., Link, E., Baeuerle, P.A., Bose, Jr., H.R. and Verma, I.M.
    The rel-associated pp40 protein prevents DNA binding of rel and NFκB: relationship with IκBβ and regulation by phosphorylation. 
    Genes & Dev. 5, 1464-1476. (1991)
  • Inoue, J., Kerr, L.D., Ransone, L.J., Bengal, E., Hunter T. and Verma, I.M. 
    c-rel activates but v-rel suppresses transcription from κB sites. 
    Proc. Natl. Acad. Sci. USA 88, 3715-3719. (1991)
  • Harayama, T., Yanda, R., Akiyama, T., Tanaka, M., Fujita, Y and Yoneda, F. 
    On the Repair of Thymine and Thymidine Bromohydrins: A Possible New Model for the damage and Repair of Nucleic Acids. 
    Chem. Pharm. Bull. 39, 612-615. (1991)
  • Akiyama, T., Yoneda, F., Tanaka, K., Kuwahara, J., and Sugiura, Y. 
    Synthesis and Characterization of Flavin Modified Oligodeoxribonucletide. 
    Nucleic Acids Res., Symp.Ser. 22, 69-70. (1991)

 

日本語総説(井上 純一郎 教授 執筆)

 

  • 井上純一郎 NFκB --まだまだあるその巧妙な制御機構
    実験医学 Vol.21 No.2(増刊)60-65 (2003) 羊土社
  • 井上純一郎 TRAF6によるサイトカインシグナルの伝達メカニズム
    Molecular Medicine Vol.39 免疫2003 (2002) 
  • 井上純一郎 TRAF6シグナルの生理的役割
    Molecular Medicine Vol.37 臨時増刊 免疫2000-2001 (2000) 110-117,中山書店
  • 井上純一郎 TRAFファミリー:サイトカインシグナルを伝達するアダプタータンパク質
    実験医学 Vol.18(No.3) 330-337 (2000) 羊土社
  • 井上純一郎 Rel/NFκBファミリーの活性制御機構とその生理機能
    がん遺伝子 がん抑制遺伝子 152-159(1998)中外医学社
  • 井上純一郎 TRAFファミリータンパク質によるシグナル伝達
    Molecular Medicine免疫 1998-99 臨時増刊2-6,中山書店
  • 井上純一郎 NF-κB研究におけるbig News -IκBキナーゼがついに明らかに!-
    細胞工学 vol.17 No1 65-67,(1998) 秀潤社
  • 井上純一郎 TRAFファミリー蛋白質が伝達するB細胞増殖シグナルとB細胞増殖シグナルとLMP1蛋白質による発癌機構
    日本臨床 55(No. 2 )29-34,(1997) 日本臨床社
  • 井上純一郎 B細胞の活性化とCD40シグナル
    臨床免疫 Culn. Immunol., 28, 1516-1521 (1996) 科学評論社
  • 井上純一郎・仙波憲太郎 cDNAクローニング
    ザ・プロトコールシリーズ (1996)羊土社
  • 井上純一郎 免疫系におけるRel/NFκBファミリーの活性化と機能
    Molecular Medicine 免疫 1996-97 岸本忠三 編集 10-16,(1996) 中山書店

 

日本語総説(秋山 泰身 准教授 執筆)

 

  • 秋山泰身・井上純一郎 免疫応答とリンパ組織構築の制御におけるTRAF6の役割
    実験医学 vol.25, No.8, 1172-1178, (2007)、 羊土社
  • 秋山泰身・井上純一郎 自己寛容成立におけるTRAF6の役割
    Annual Review 免疫, p195-203, (2007)、 中外医学社
  • 秋山泰身・井上純一郎 TRAF6による胸腺微小環境形成とT細胞トレランスの制御
    Molecular Medicine vol. 42, p125-132 (2005)、臨時増刊号 免疫2006、 中山書店
  • 秋山泰身・井上純一郎 免疫系の自己ー非自己識別機構とTRAF6
    実験医学 vol.23, No.20, (2005)、 増刊号 サイトカインの多彩な機能と臨床応用、羊土社
  • 秋山泰身・井上純一郎 TRAF6による自己免疫抑制と胸腺構築の制御
    ファルマシア vol. 41, No. 12, 1155-1158 (2005)
  • 秋山泰身、井上純一郎 「リンパ組織の形成とTRAF6」
    臨床免疫、43 (1): 18-23, (2005)
  • 秋山泰身 3本鎖形成オリゴヌクレオチドを利用した遺伝子制御とDNAベンド。
    有機合成化学協会誌, Vol. 57, No. 3, 194-205 (1999)
  • Yoneda, F., Akiyama, T. Ohno, M., Yanda, R., and Harayama, T. On the Conversion of Thymidine Phosphate Bromohydrins to Thymidine Phosphates: A Model Reaction for the Repair of Oxidized Nucleotides.
    Yakugaku Zasshi 111, 284-292 (1991).